Takanori Hasegawa, Ph.D

Assistant Professor at The Univerity of Tokyo

Co-founder / Collaborative Researcher at miup Inc.

Technology Advisor at Panasonic Inc. and CareLab Inc.

ABOUT

I'm an Assistant Professor at The University of Tokyo, a Co-founder / Collaborative Researcher at miup Inc., Technical Advisors at Panasonic, Inc. and CareLab Inc. with expertise of Computational Statistics, Time-series Analysis (Data Assimilation), Applied Statistics, Bioinformatics, and Machine Learning. I'm interested in applying technological developments in computer science and biotechnology for the innovation of human being. Also, I'm currently very interested in financial strategy and business development (focusing on these roles in miup Inc.).

In the field of Computational and Applied Statistics, I have developed several types of data assimilation methodologies, e.g., linear/nonlinear Kalman filters. In practical research of Computational Biology and Genomics, I have analyzed human genome/health and epidemiological data such as time-series medical examination data to predict future health risks and cancer genome sequencing data for the elucidation of immuno-cancer relationship and the development of personalized medicine. In Business field, the current interest is to develop several types of artificial intelligence systems utilizing, e.g., Bayesian statistical inference, for the application of medicine, health and nursing care, and immune-cancer therapies, and also to design financial and business strategies.

I'm also studying modern history, classical strategy, e.g., Hundred Schools of Thought and The Prince, geopolitics and philosophy as life works.

EDUCATION

Doctor of Informatics
Department of Intelligence Science and Technology
Graduate School of Informatics, Kyoto University
(Bioinformatics Center, Institute for Chemical Research, Kyoto University)

Doctoral Program
Thesis Title: Reconstructing Biological Systems Incorporating Multi-Source Biological Data via Data Assimilation Techniques

From Apr. 2012 to Jan. 2015 (Completion in shortened years)

Master of Information Science and Technology
Department of Computer Science
Graduate School of Information Science, The University of Tokyo
(Human Genome Center, Institute of Medical Science, The University of Tokyo)

Master's Program
Thesis Title: Intracellular Systems Analysis by Assimilating Large Scale Biological Data and Pathway Simulation

From Apr. 2010 to Mar. 2012

Bachelor of Engineering
Facalty of Science and Engineering, Waseda University

Baccalaureate Degree Program
Thesis Title: 遺伝子ネットワーク推定とデータ同化による細胞内ネットワークシミュレーションモデルの構築

From Apr. 2006 to Mar. 2010



CURRENT WORK

Assistant Professor
Health Intelligence Center, The Institute of Medical Science, The University of Tokyo

Our research topics are analyzing human genome, transcriptome, epigenome, metagenome and clinical data for personalized and preventive medicine through modeling, prediction and inference of disease and health systems. For example, we have been undertaking immunological cancer genome and metagenome analysis based on statistical and machine learning methods.

Especially, in the field of statistical science, my speciality is computational statistics and stochastic simulation, such as data assimilation and have published many research papers.

October 2015 - Current

Co-founder / Collaborative Researcher
miup

miup Inc. is trying to establish "Integrated Healthcare Eco-System" using IoT technology and clinical A.I. system starting from developing countries to developed countries. Firstly, we have launched a home delivery health-care service in Bangladesh.

My role is to design business strategy, make financial indication and capital policy, raise funds, and manage our team.

Our system has a highly complicated statistical structure to enhance the quality of the inference, estimate the confidence level of the conclusions, and predict the future risks through Bayesian statistics and machine learning.

September 2015 - Current

Technology Advisor
Panasonic Inc.

Detail is Confidential: Production and experiment optimization of an image processing devision based on Bayesian framework.

Apr 2017 - Current

Collaborative Project / Technology Advisor
CareLab Inc.

Still Confidential:

Apr 2017 - Current



PAST WORK

Technology Advisor
Medley, Inc.

We developed an automated consulting system termed Mogul for medical treatment. This system is a type of artificial intelligence and based on a simple Bayesian inference procedure (Its concept is similar to the one in miup Inc. but this version is a little bit older). Also, a pandemic prediction system for the degree of future influenza epidemic has been released in the website.

February 2015 - April 2017

Technology Advisor
Nadia Inc.

Confidential: Education for A.I. development especially for image processing.

Mar 2016 - Feb 2017

Technology Advisor
Heathcare online

Confidential: Consultation of data science and A.I. business.

Mar 2016 - Feb 2016

Assistant Professor
Tohoku Medical Megaban Organization, Tohoku University

The main topic was genome wide association study and to develop novel strategies for analyzing rare variants association test. Our developed method is highly efficient and available to WGS data within a reasonable time. In addition, we proposed a novel statistical method termed kernel Bayes' approximate Bayesian computation filtering for estimation of parameter values in stochastic simulation models.

February 2015 - September 2015

Co-founder / CTO (Technology Advisor, Feb. 2015-)
CRUNCHERS Inc.

We developed automated evaluation systems for predicting the profit of books and cinema. The former system was integrated to Medley, Inc. as CRUNCH MAGAZINE. For the latter system, I still have advised the statistical perspective of applying the developed simulation system (CRUNCH CINEMA) to the collaborative companies. In addition, since we're collaborating with major studios and major entertainment companies in JAPAN and USA, we have extended and developed CRUNCH CINEMA for the application of general purpose.

July 2013 - September 2015

Research Fellow
Japan Society for The Promotion of Science

The research topic was Reconstructing Biological Systems Incorporating Multi-Source Biological Data via Data Assimilation Techniques.

April 2012 - January 2015



PUBLICATIONS

Journal Paper
[J1] T. Hasegawa, M. Nagasaki, R. Yamaguchi, S. Imoto and S. Miyano. An efficient method of exploring simulation models by assimilating literature and biological observational data, BioSystems, vol.121, pp.54-66, 2014.
[J2] T. Hasegawa, R. Yamaguchi, M. Nagasaki, S. Miyano and S. Imoto. Inference of gene regulatory networks incorporating multi-Source biological knowledge via a state space model with L1 regularization, PLoS ONE, vol.9(8), e105942, 2014.
[J3] T. Hasegawa, T. Mori, R. Yamaguchi, S. Imoto, S. Miyano and T. Akutsu. An efficient data assimilation schema for restoration and extension of gene regulatory networks using time-course observation data, Journal of Computational Biology, vol.21(11), pp. 785-798, 2014.
[J4] T. Hasegawa, T. Mori, R. Yamaguchi, T. Shimamura, S. Miyano, S. Imoto and T. Akutsu. Genomic data assimilation using a higher moment filtering technique for restoration of gene regulatory networks. BMC Systems Biology, vol.9(14), 2015.
[J5] T. Hasegawa, A. Niida, T. Mori, T. Shimamura, R. Yamaguchi, S. Miyano, T. Akutsu and S. Imoto. A likelihood-free filtering method via approximate Bayesian computation in evaluating biological simulation models. Computational Statistics and Data Analysis, vol.94, pp.63-74, 2016.
[J6] J. Kurashige, T. Hasegawa (Equal First), et al. Integrated molecular profiling of human gastric cancer identifies DDR2 as a potential regulator of peritoneal dissemination. Scientific Reports, vol.6, pp.22371, 2016.
[J7] E. Ayada, T. Hasegawa, A. Niida, S. Miyano and S. Imoto. Binary contingency table Method for analyzing gene mutation in cancer genome. International Journal of Bioinformatics Research and Applications (11th The International Symposium on Bioinformatics Research and Applications), vol.12(3), pp.211-226, 2016.
[J8] K. Kojima, Y. Kawai, N. Nariai, T. Mimori, T. Hasegawa and M. Nagasaki. Short tandem repeat number estimation from paired-end sequence reads by considering unobserved genealogy of multiple individuals. BMC Genomics (11th The International Symposium on Bioinformatics Research and Applications), vol.17(Suppl. 5), pp.465--476, 2016.
[J9] S. Koshiba, Y. Yamaguchi, K. Kojima, T. Hasegawa, et al. The structural origin of metabolic quantitative diversity. Scientific Reports, vol.6, pp.31463, 2016.
[J10] T. Hasegawa, K. Kojima, Y. Kawai, K. Misawa, T. Mimori and M. Nagasaki. AP-SKAT: highly-efficient genome-wide rare variant association test, BMC Genomics, vol.17(1), pp.1-8, 2016.
[J11] T. Morita, A. Rahman, T. Hasegawa, A. Ozaki, T. Tanimoto. The Potential Possibility of Symptom Checker, International Journal of Health Policy and Management, 2017.

Peer-reviewed Oral Presentation with Proceeding/Lecture Note (Not Published in Journals)

(I haven't Write Other Oral Presentations Because I had So Many Such Ones... )
[C1] T. Hasegawa, R. Yamaguchi, M. Nagasaki, S. Imoto and S. Miyano. Poster: Comprehensive pharmacogenomic pathway screening by data assimilation, Proc. Computational Advances in Bio and Medical Sciences (ICCABS), 2011 IEEE 1st International Conference on, pp.246-246, 2011.
[C2] T. Hasegawa, R. Yamaguchi, M. Nagasaki, S. Imoto and S. Miyano. Comprehensive pharmacogenomic pathway screening by data assimilation, Proc. 7th International Symposium on Bioinformatics Research and Applications, volume 6674 of Lecture Notes in Computer Science, pp.160-171. Springer Berlin Heidelberg, 2011.
[C3] T. Hasegawa, S. Hayashi, E. Shimizu, S. Mizuno, R. Yamaguchi, S. Miyano, H. Nakagawa, and S. Imoto. An in silico automated pipeline to identify tumor specic neoantigens from whole genome and exome sequencing data. Proc. 12th International Symposium on Bioinformatics Research and Applications, 2016.


Downloads

VARSSM.jar[J2]


HMEnPF.jar[J4]


APSKAT[J10]


Neoantimon[C3]



Activity

長谷川嵩矩:東京大学医科学研究所 ヘルスインテリジェンスセンター 助教。博士(情報学)。修士・博士課程に於いて情報科学を専攻、統計的時系列解析と生命情報学研究(生体内システムの統計的解析手法開発)の研究に着手。ベイズ推論や計算機統計、ゲノム解析を含む生命情報学を専門とし、特に状態空間モデルの理論的進展に関する幅広い知見を有する。

京都大学大学院 情報学研究科 博士課程の在学中に情報科学技術と芸術の融合を行うべく、CRUNCHERS株式会社を共同創業し、自然言語処理技術を中核とした小説の評価システム(CRUNCH MAGAZINE)と統計的シミュレーションを用いた映画の興行収益予測システム(CRUNCH CINEMA)を開発(前者は2015年1月に事業譲渡)。その後、博士課程を短縮修了して東北大学東北メディカル・メガバンク機構助教に着任し、疾患と遺伝子変異の関連解析並びに希少変異の網羅的かつ高速な解析手法を開発を行う。また同時期からMedley, Inc.の技術顧問に着任し、ベイズ学習を用いた医療用疾患推定システム(Mogul)やインフルエンザの感染予測技術などを開発・提供する。

現職では、複雑な性質を持つ時系列データの内部状態とその将来状態を正確に予測する統計理論研究、ICGCプロジェクトにおける免疫ゲノムデータ解析と解析ライブラリ開発、コホートデータを用いたGWASの層別化解析手法の開発や時系列の検査値・生活習慣データとゲノムデータを統合的に利用することで将来の健康状態を予測する統計科学手法の開発などを行う。

大企業の生産及び実験最適化やスタートアップ企業のAI (統計科学、機械学習) 開発に関する技術顧問を担っている他、特に東大発ベンチャー企業であるmiup社では共同創業者として資本政策や企業価値評価、ビジネス戦略立案、対外交渉の役割を担っている。大規模医療データ解析や医療産業における新たな働き方の提供に関する共同研究も行っており、臨床医学や臨床検査、医療を含む多くの現場における労働法や派遣法の運用に関する知見も有している。

Research Bio: Takanori Hasegawa received BS in Engineering from Waseda university, MS in Information Science and Technology from The university of Tokyo, and PhD in Informatics from Kyoto University in 2010, 2012 and 2015, respectively. He is currently an Assistant Professor of Health Intelligence Center, Institute of Medical Science, University of Tokyo. His current research interests cover time series analysis, data assimilation, Bayesian statistical inference, health informatics, genome wide association study, immunological and cancer genome analysis.



CONTACT

Email
t-hasegw@ims.u-tokyo.ac.jp

SOCIAL LINKS